Anoxia and Sickling

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Exertional sickling: questions and controversy

Sickle cell trait (SCT) occurs in about 8% of African-Americans and is often described to be of little clinical consequence. Over time, a number of risks have emerged, and among these are rare but catastrophic episodes of sudden death in athletes and other individuals associated with physical activities which is often described as exercise collapse associated with sickle trait (ECAST). Despite ...

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Erythrocyte sickling during exercise and thermal stress.

OBJECTIVE To examine effects of exercise in the heat and fluid intake on erythrocyte sickling and neutrophil activation in carriers of sickle cell trait (HbAS). DESIGN, SETTING, AND PARTICIPANTS Six African American men (2 HbAS; 42% HbS, 4 HbAA; 20.7 +/- 0.8 years; 87.4 +/- 9.6 kg) participated in 2 randomized sessions (separate days) each consisting of 45 minutes of brisk walking (treadmill)...

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Li+ and sickling of homozygous HbS cells.

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Red cells shrink during sickling.

Rapid transformatIon of discoid hemoglobin SS erythrocytes into grossly distorted sickled forms suggests alteration of surface/volume ratio. We, therefore, examined the effect of deoxygenation on red cell volume. ‘31llaholed albumin was used as a marker of plasma volume in normal (Hb AA), sickle (Hb SS), and sickle-C (Hb SC) blood. Heparinized blood was incubated for 30 mm at 37#{176}Cin a tpno...

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ژورنال

عنوان ژورنال: BMJ

سال: 1963

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.5368.1342-a